Decreased expression of HLA‐DR on monocytes (mHLA‐DR) is a reliable indicator of immunosuppression in patients with sepsis and is correlated with increased risk of secondary infection and mortality. A flow cytometry‐based laboratory developed test for the measurement of mHLA‐DR in whole blood was validated for clinical trial enrollment, which is considered medical decision‐making, for patients with severe sepsis or septic shock.

中文翻译：

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流式细胞仪检测单核细胞上 HLA-DR 表达，经验证可作为脓毒症临床试验的生物标志物

单核细胞上 HLA-DR 的表达降低 (mHLA-DR) 是脓毒症患者免疫抑制的可靠指标，并且与继发感染和死亡率的风险增加相关。一项基于流式细胞术的实验室开发的用于测量全血中 mHLA-DR 的测试已被验证用于严重脓毒症或感染性休克患者的临床试验登记，这被认为是医疗决策。