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New analyses provide supportive evidence for specific genes related to bipolar disorder
Bipolar Disorders ( IF 5.4 ) Pub Date : 2021-01-11 , DOI: 10.1111/bdi.13044
John I Nurnberger 1
Affiliation  

A recent article by Franklin and Dwyer1 analyzes genes identified in two previous genome‐wide association studies (GWAS) of bipolar disorder2,3. They establish that the 230 genes identified in the two studies are evolutionarily conserved (in C elegans and zebrafish but not in drosophila), that they contain regions of homology and are highly interactive, and that some of them are clustered in syntenic groupings on chromosomes in humans and zebrafish.

中文翻译:

新分析为与躁郁症相关的特定基因提供了支持性证据

富兰克林和德威尔1的最新文章分析了双极性障碍2,3的两个先前的全基因组关联研究(GWAS)中鉴定的基因。他们确定,在两项研究中鉴定出的230个基因在进化上是保守的(在秀丽隐杆线虫和斑马鱼中,但在果蝇中则不是),它们具有同源性区域并具有高度的相互作用,并且其中一些聚集在染色体的同系群中。人类和斑马鱼。
更新日期:2021-01-12
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