Objective

Although food protein–induced enterocolitis syndrome (FPIES) was first described approximately 50 years ago and research is increasing, there are still considerable unmet needs in FPIES. This article catalogs the areas of progress and areas for further research.

Data Sources

Through our personal experiences in caring for patients with FPIES, our personal research, and a review of the existing FPIES literature as indexed in PubMed, we explored what is known and what is needed in FPIES.

Study Selections

The studies that have improved the knowledge of FPIES, defined phenotypes, allowed for better-informed management of FPIES, and laid the groundwork for further research.

Results

Further research is needed in the areas of prevalence, natural history, trigger foods, threshold doses, how and when to perform oral food challenges, and immunopathogenesis of this disorder. Development of a biomarker and determination of the best method to treat reactions is also needed. Furthermore, FPIES has a substantial psychosocial and economic impact on families, and more research is needed in developing and implementing ameliorating strategies.

Conclusion

By partnering together, health care providers, advocacy organizations, and families can continue to advance our understanding and improve the care of patients and families living with FPIES.

中文翻译：

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食物蛋白诱导的小肠结肠炎综合征的演变

客观的

尽管大约 50 年前首次描述了食物蛋白诱导的小肠结肠炎综合征 (FPIES)，并且研究正在增加，但 FPIES 仍有相当多的需求未得到满足。本文列出了进展领域和需要进一步研究的领域。

数据源

通过我们在照顾 FPIES 患者方面的个人经验、我们的个人研究以及对 PubMed 中索引的现有 FPIES 文献的回顾，我们探索了 FPIES 中已知的内容和需要的内容。

研究选择

这些研究提高了 FPIES 的知识，定义了表型，可以对 FPIES 进行更明智的管理，并为进一步研究奠定了基础。

结果

需要在患病率、自然史、触发食物、阈值剂量、如何以及何时进行口服食物挑战以及这种疾病的免疫发病机制等领域进行进一步的研究。还需要开发生物标志物并确定治疗反应的最佳方法。此外，FPIES 对家庭有重大的社会心理和经济影响，需要更多的研究来制定和实施改善策略。

结论

通过合作，医疗保健提供者、倡导组织和家庭可以继续增进我们的理解并改善对患有 FPIES 的患者和家庭的护理。