The COVID-19 pandemic has raised many issues not the least of which is the reason for its high variability in consequences to the infected person. In this opinion letter, we advocate that the dose and presentation of the infecting virus is a major factor that affects whether the outcome is subclinical, tissue damaging or even lethal following infection. We briefly describe the known effects of virus dose on the course COVID-19 and discuss practical maneuvers as well as largely untested procedures that can raise the threshold dose needed to break through barriers of resistance.

中文翻译：

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COVID-19：疾病还是没有疾病？- 就是那个问题。这是愚蠢的剂量！

COVID-19大流行引发了许多问题，这尤其是其对受感染者后果的高度可变性的原因。在此意见书中，我们主张感染病毒的剂量和呈递是影响感染后结局是否为亚临床，组织破坏乃至致死的主要因素。我们简要描述了病毒剂量对COVID-19过程的已知影响，并讨论了实际操作以及未经测试的程序，这些程序可以提高突破耐药性障碍所需的阈值剂量。