A comprehensive strategy for manufacturing a novel sorbent based on magnetic molecularly imprinted polymers (MMIPs) is addressed for selective capture of oxytetracycline from seawater. The novel MMIPs were synthesized by nano-Fe₃O₄ as sacrificial matrix and adsorption properties of the polymers demonstrate rapid adsorption kinetics, high adsorption capacity, and specificity towards oxytetracycline provided by the core-shell composite structure. After screening the critical parameters by multivariate optimization, a magnetic imprinting solid phase extraction method combined with fluorescence spectrophotometry (MMIP-SPE-FL) was constructed for sensitive determination of oxytetracycline in seawater samples. The results show a good linear response dependence on the spiking concentration of 3–100 μg L⁻¹, and a satisfactory limit of detection of 0.7 μg L⁻¹ after the MMIP-SPE preconcentration. Seven seawater samples from Jiaozhou bay were analyzed to give recoveries in the range of 89.75–107.65% with relative standard deviation values of less than 5.44% (n = 3).

提出了一种基于磁性分子印迹聚合物（MMIP）制造新型吸附剂的综合策略，用于从海水中选择性捕获土霉素。通过纳米Fe ₃ O ₄合成新型MMIPs聚合物的牺牲基质和吸附性能表明其具有快速的吸附动力学，高吸附能力和核壳复合结构提供的对土霉素的特异性。通过多变量优化筛选关键参数后，构建了磁印固相萃取结合荧光分光光度法（MMIP-SPE-FL）的方法，用于灵敏测定海水样品中的土霉素。结果显示出良好的线性上的3-100微克L上的尖峰浓度响应依赖性^-1，和检测的0.7微克L的令人满意的极限^-1MMIP-SPE预浓缩后。分析了胶州湾的7个海水样品，其回收率在89.75–107.65％之间，相对标准偏差值小于5.44％（n = 3）。