Cardiovascular aging and longevity are interrelated through many pathophysiological mechanisms. Many factors that promote atherosclerotic cardiovascular disease are also implicated in the aging process and vice versa. Indeed, cardiometabolic disorders such as hyperglycemia, insulin resistance, dyslipidemia, and arterial hypertension share common pathophysiological mechanisms with aging and longevity. Moreover, genetic modulators of longevity have a significant impact on cardiovascular aging. The current knowledge of genetic, molecular, and biochemical pathways of aging may serve as a substrate to introduce interventions that might delay cardiovascular aging, thus approaching the goal of longevity. In the present review, the authors describe pathophysiological links between cardiovascular aging and longevity and translate these mechanisms into clinical data by reporting genetic, dietary, and environmental characteristics from long-living populations.

中文翻译：

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心血管衰老和长寿

心血管衰老和长寿通过许多病理生理机制相互关联。许多促进动脉粥样硬化心血管疾病的因素也与衰老过程有关，反之亦然。事实上，心脏代谢紊乱如高血糖、胰岛素抵抗、血脂异常和动脉高血压与衰老和长寿具有共同的病理生理机制。此外，长寿的遗传调节剂对心血管衰老有显着影响。目前对衰老的遗传、分子和生化途径的了解可以作为引入干预措施的基础，从而延缓心血管衰老，从而实现长寿的目标。在本次审查中，