Strecker reaction is widely applied for the synthesis of amino acids from aldehydes, amines and cyanides. Herein, we report the FeI₂-catalyzed reductive Strecker type reaction of formamides instead of aldehydes to produce amino acetonitriles. The challenging capture of carbinolamine intermediates by CN⁻ was achieved via Fe catalysis. This approach afforded better yields than the use of Ir- or Rh-catalysts. The application ability of this methodology is demonstrated by 1) one-pot construction of (¹³C labeled) complex molecules from CO₂ via amino acetonitrile intermediates and 2) convenient production of homologated carboxylic acids from aldehydes.

斯特雷克反应被广泛应用于由醛，胺和氰化物合成氨基酸。在本文中，我们报道了FeI ₂催化的甲酰胺而不是醛的还原斯特雷克型反应生成氨基乙腈。通过CN甲醇胺中间体的具有挑战性的拍摄^-达到了通过铁催化。与使用Ir或Rh催化剂相比，此方法可提供更好的产率。这种方法的应用能力通过以下方式得到证明：1）通过氨基乙腈从一氧化碳（CO ₂）中一锅构建（¹³ C标记的）复杂分子，以及2） 由醛方便地生产同系羧酸。