To develop the isoprenaline (ISN) sensor with a simple and convenient synthesis process, the novel gadolinia doped zinc oxide is decorated on graphene oxide (GZO@GO) nanocomposite. The GZO@GO was synthesized through a cost-effective coprecipitation approach. XRD, FT-IR, and XPS, FE-SEM, and HR-TEM studies were used to investigate the physicochemical properties of as-prepared nanomaterials. The synthesized GZO@GO composite was successfully modified with a glassy carbon electrode (GCE) and employed as a superior electrocatalyst and challenging sensing platform for ISN detection. Electron transferability of these supported catalysts is probed by electrochemical techniques i.e. CV and EIS using K₃[Fe(CN)₆]/K₄[Fe(CN)₆] as a redox probe. The electrochemical oxidation of ISN based on GZO@GO was monitored by CV and DPV by optimal conditions. The present sensor showed a dynamic linearity is 0.02 μM–122.1 μM; regression equation; I_pa(μM) = 8.1847 (c/μM)–0.4502 (R² = 0.995) with the detection limit is achieved 0.003 μM. Also, the modified electrode demonstrates good long-term reliability, reproducibility, and good anti-interference ability. The GZO@GO modified electrode displayed higher electrocatalytic activity towards ISN oxidation due to the increasing adsorption of ISN on GZO@GO modified electrode surfaces. Finally, our proposed material was applied for the ISN determination in a human urine sample with satisfactory recovery results. This work provides insights into the eco-friendly synthesis of nanocatalyst (GZO@GO) for the ISN sensor.

为了用简单便捷的合成方法开发异戊二烯（ISN）传感器，将新型氧化g掺杂的氧化锌装饰在氧化石墨烯（GZO @ GO）纳米复合材料上。GZO @ GO是通过具有成本效益的共沉淀方法合成的。XRD，FT-IR和XPS，FE-SEM和HR-TEM研究用于研究制备的纳米材料的理化性质。合成的GZO @ GO复合材料已成功用玻璃碳电极（GCE）改性，并被用作ISN检测的优良电催化剂和具有挑战性的传感平台。这些负载型催化剂的电子转移性通过电化学技术（即CV和EIS）使用K ₃ [Fe（CN）₆ ] / K ₄ [Fe（CN）₆]作为氧化还原探针。在最佳条件下，通过CV和DPV监测了基于GZO @ GO的ISN的电化学氧化。本传感器显示动态线性为0.02 μM–122.1μM；回归方程 I _pa（μM）= 8.1847（c /μM）–0.4502（R ²= 0.995），检出限达到0.003μM。而且，改性电极表现出良好的长期可靠性，可再现性和良好的抗干扰能力。由于IZO在GZO @ GO修饰电极表面上的吸附增加，因此GZO @ GO修饰电极对ISN氧化表现出更高的电催化活性。最后，我们提出的材料用于人尿液样品中的ISN测定，回收率令人满意。这项工作为ISN传感器的纳米催化剂的环保合成（GZO @ GO）提供了见解。