INTRODUCTION Parkinson's disease (PD) is a common neurodegenerative disorder, with a higher risk of death than general population. Deep Brain Stimulation (DBS) has been used to treat PD for more than 2 decades, but few studies exist concerning mortality in this subset of patients. Our goal is to analyse mortality in PD patients treated with DBS in our centre. METHODS retrospective evaluation of clinical files of patients with PD who underwent DBS surgery consecutively between October 2002 and May 2019. RESULTS 346 patients were included in the analysis, 60 % male, with a mean age at disease onset of 48± 8 years (18-64), mean age at surgery of 60 ± 7 years (33-75), and mean disease duration until surgery of 14 ± 6 years (3-52). Mean follow-up after surgery was 7 ± 4 years (range 1-17). Overall mortality rate was 17.9 % and mean age at time of death was 71 ± 6 years. The main causes of death were pneumonia, dementia and acute myocardial infarction. In our series, male gender and disease duration until surgery were the only predictors of mortality in multivariate analysis. CONCLUSION Our study showed a long-term survival higher than previously described, and suggests that the treatment of patients with shorter disease evolution might have a survival benefit. The leading causes of death in PD patients treated with DBS seems unrelated to surgery, as the main causes of death are comparable to non-DBS patients.

中文翻译：

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在参考中心接受深部脑刺激治疗的帕金森病患者的长期死亡率

引言 帕金森病 (PD) 是一种常见的神经退行性疾病，其死亡风险高于普通人群。深部脑刺激 (DBS) 已用于治疗 PD 超过 2 年，但很少有关于这部分患者死亡率的研究。我们的目标是分析在我们中心接受 DBS 治疗的 PD 患者的死亡率。方法 回顾性评估 2002 年 10 月至 2019 年 5 月期间连续接受 DBS 手术的 PD 患者的临床档案。结果 346 名患者被纳入分析，60% 为男性，平均发病年龄为 48±8 岁（18- 64)，平均手术年龄为 60 ± 7 岁 (33-75)，平均疾病持续时间为 14 ± 6 年 (3-52)。术后平均随访时间为 7 ± 4 年（范围 1-17）。总死亡率为17。9 %，死亡时的平均年龄为 71 ± 6 岁。死亡的主要原因是肺炎、痴呆和急性心肌梗死。在我们的系列中，男性和手术前的疾病持续时间是多变量分析中死亡率的唯一预测因素。结论 我们的研究显示长期生存率高于先前描述的，并表明治疗疾病进展较短的患者可能具有生存获益。接受 DBS 治疗的 PD 患者的主要死亡原因似乎与手术无关，因为主要死亡原因与非 DBS 患者相当。结论 我们的研究显示长期生存率高于先前描述的，并表明治疗疾病进展较短的患者可能具有生存获益。接受 DBS 治疗的 PD 患者的主要死亡原因似乎与手术无关，因为主要死亡原因与非 DBS 患者相当。结论 我们的研究显示长期生存率高于先前描述的，并表明治疗疾病进展较短的患者可能具有生存获益。接受 DBS 治疗的 PD 患者的主要死亡原因似乎与手术无关，因为主要死亡原因与非 DBS 患者相当。