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Effects of unilateral tDCS over left prefrontal cortex on emotion regulation in depression: Evidence from concurrent functional magnetic resonance imaging
Cognitive, Affective, & Behavioral Neuroscience ( IF 2.9 ) Pub Date : 2021-01-12 , DOI: 10.3758/s13415-020-00830-4
Wessel O van Dam 1 , Evangelia G Chrysikou 1
Affiliation  

Major depressive disorder (MDD) is the most common mood disorder and a primary cause of disability worldwide. MDD symptomatology entails disturbances in emotion regulation, namely one’s ability to modify the intensity and duration of emotional reactions towards affective events. Transcranial direct current stimulation (tDCS) has emerged as a promising treatment for MDD. Yet, positive tDCS outcomes vary across studies, while the precise effects of the procedure for cortical excitability in MDD during emotion regulation remain largely unexplored. Here, we leveraged functional magnetic resonance imaging (fMRI)-compatible tDCS technology to examine the functional consequences of a unilateral anodal tDCS montage at 1.5 mA over left PFC (area F3; with the reference electrode over an extracephalic location) for brain activity during an emotion-regulation task in MDD patients and age-matched healthy control subjects. Our results revealed down-regulation of negative emotions in the right amygdala and visual cortex of healthy controls but not MDD patients prior to stimulation, the degree of which correlated with the magnitude of the participants’ reappraisal scores. TDCS did not elicit significant changes in neural activation patterns for either group. These findings contribute to the literature on the pathophysiology of MDD by showing that a key disturbance in the disorder entails the ineffective down-regulation of activity not only within the amygdala, but also within visual cortical areas in response to negative information. Further, these results suggest that relative to bifrontal tDCS montages, unilateral stimulation of moderate intensity over left PFC may not be sufficient to elicit therapeutic effects for MDD.



中文翻译:

左侧前额叶皮质单侧 tDCS 对抑郁情绪调节的影响:来自同时功能磁共振成像的证据

重度抑郁症 (MDD) 是最常见的情绪障碍,也是全世界残疾的主要原因。MDD 症状需要情绪调节障碍,即一个人改变对情感事件的情绪反应的强度和持续时间的能力。经颅直流电刺激 (tDCS) 已成为 MDD 的一种有前途的治疗方法。然而,积极的 tDCS 结果因研究而异,而在情绪调节期间 MDD 中皮质兴奋性程序的确切影响仍然很大程度上未探索。在这里,我们利用与功能磁共振成像 (fMRI) 兼容的 tDCS 技术来检查左侧 PFC(区域 F3;区域 F3;在 MDD 患者和年龄匹配的健康对照受试者的情绪调节任务期间,将参考电极置于脑外位置)用于大脑活动。我们的研究结果显示,在刺激前,健康对照组的右侧杏仁核和视觉皮层的负面情绪下调,而 MDD 患者则没有,其程度与参与者重新评估分数的大小相关。TDCS 没有引起任何一组的神经激活模式的显着变化。这些发现有助于MDD的病理生理学文献,表明该疾病的一个关键障碍不仅导致杏仁核内活动的无效下调,而且还导致视觉皮层区域内对负面信息的反应。更远,

更新日期:2021-01-12
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