The combination of radiotherapy and chemotherapy is a common and useful treatment mode for tumours. But traditional methods inevitably lead to a variety of side effects. A drug delivery system (DDS), which has good biocompatibility and strong anti-tumour ability, is expected to solve this problem. Studies have shown that Ce-based nanoparticles (NPs) have good radiosensitization effect through the photoelectric effect. Hence, cisplatin-loaded LiLuF₄ :Ce³⁺scintillation NPs (NP + Cis) were first constructed in this study, which was synthesized by the crystal precipitation method and characterized by transmission electron microscopy (TEM). Subsequently, its toxicity was verified, and the radiosensitization effect and basic radiosensitization mechanism on tumour cells and tumour-bearing mice were researched. Results showed that NP + Cis triggered massive DNA damage and effectively inhibited cell viability in vitro under the exposure of X-ray irradiation (IR). Moreover, the experiments in vivo showed that the NP + Cis had higher biosafety, which could absorb enough irradiation and produce a synergistic inhibitory effect on tumours through the releasing of Cis. NP + Cis can improve the performance of DDS in chemoradiotherapy.

中文翻译：

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负载顺铂的铈基纳米颗粒用于肿瘤放射治疗。

放射疗法和化学疗法的结合是肿瘤的常见且有用的治疗方式。但是传统方法不可避免地会导致各种副作用。具有良好的生物相容性和强大的抗肿瘤能力的药物递送系统（DDS）有望解决该问题。研究表明，基于Ce的纳米颗粒（NPs）通过光电效应具有良好的放射增敏作用。因此，顺铂加载的LiLuF₄：Ce ³⁺本研究首先构建了闪烁的NPs（NP + Cis），通过晶体沉淀法合成了该NPs，并通过透射电子显微镜（TEM）对其进行了表征。随后，对其毒性进行了验证，并研究了其对肿瘤细胞和荷瘤小鼠的放射增敏作用和基本的放射增敏机理。结果显示，在X射线辐射（IR）的照射下，NP + Cis会引发大量DNA损伤并有效抑制体外细胞活力。此外，体内实验表明，NP + Cis具有更高的生物安全性，可以吸收足够的辐射，并通过释放Cis对肿瘤产生协同抑制作用。NP + Cis可以改善DDS在放化疗中的性能。