The fast-growing use of supramolecular hydrogelators as biomaterials for a variety of applications, ranging from wound healing to drug delivery to tissue engineering, has highlighted the importance of synthetic design over recent years. Here, we report a new class of nanosheet stereocomplexes in aqueous solution and at physiological conditions (i. e., pH7.4), which are formed by physically mixing right- and left-handed tripeptide supramolecular hydrogelators without any external stimulus. Such tripeptides were obtained by incorporating either α-aminoisobutyric acid (Aib, U) or alanine (Ala, A) at the C-terminus or middle position of known peptide hydrogelators containing naphthalene and two phenylalanine residues. For hydrogels of these peptides, our results show that their morphologies and physical properties changed upon mixing with the L- and D-forms of the peptides forming suspension stereocomplexes. These interactions reduced molecular mobility by forming new structures with new properties and, therefore, increased the thermal stability of the compound promising for numerous medical applications.

中文翻译：

---

三肽立体复合纳米形式的物理性质。

超分子水凝胶化剂作为生物材料的快速增长的使用，从伤口愈合到药物输送再到组织工程，已成为近年来合成设计的重要性。在这里，我们报告了在水溶液中和在生理条件下（即pH7.4）的一类新的纳米片立体复合物，它们是通过物理混合右手和左手三肽超分子水凝胶剂而形成的，没有任何外部刺激。通过在已知的含有萘和两个苯基丙氨酸残基的肽水凝胶化剂的C-末端或中间位置掺入α-氨基异丁酸（Aib，U）或丙氨酸（Ala，A）获得三肽。对于这些肽的水凝胶，我们的结果表明，它们的形态和物理性质在与形成悬浮立体复合物的肽的L和D形式混合后发生了变化。这些相互作用通过形成具有新特性的新结构而降低了分子迁移率，因此增加了该化合物的热稳定性，有望在许多医疗应用中使用。