Gene therapy has been widely studied in colon cancer treatment. However, effective delivery of genes is a limitation for clinical applications. In the research, DOATP/mPEG-PLA-mPEG (DPLP) nanoparticles carrying the vesicular stomatitis virus matrix protein plasmid (pVSVMP) was used for colon cancer therapy, resulting in high transfection efficiency and expression efficiency in CT26 cells. Moreover, the DPLP-pVSVMP complex was provide with apoptosis induction and proliferation suppression of CT26 cells in vitro and can efficiently inhibit tumor growth in murine colon cancer model by inducing apoptosis, suppressing proliferation and angiogenesis. These results suggest that DPLP nanoparticles delivering pVSVMP might be a latent therapeutic avenue for colon cancer.

中文翻译：

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高分子载体加载水泡性口腔炎病毒基质蛋白基因的结肠癌治疗。

基因疗法已经在结肠癌治疗中被广泛研究。然而，基因的有效传递是临床应用的限制。在这项研究中，携带水泡性口炎病毒基质蛋白质粒（pVSVMP）的DOATP / mPEG-PLA-mPEG（DPLP）纳米颗粒用于结肠癌治疗，在CT26细胞中具有很高的转染效率和表达效率。而且，DPLP-pVSVMP复合物在体外具有对CT26细胞的凋亡诱导和增殖抑制作用，并且可以通过诱导凋亡，抑制增殖和血管生成而有效地抑制鼠结肠癌模型中的肿瘤生长。这些结果表明，递送pVSVMP的DPLP纳米颗粒可能是结肠癌的潜在治疗途径。