Antibiotic contaminants in aqueous media pose a serious threat to human and ecological environments. Therefore, it is necessary to develop robust strategies to detect antibiotic residues. For this purpose, a self-assembly and in situ electrochemical reduction method is utilized to tailor silver nanoparticles (AgNPs)-coated GNRs (AgNPs/GNRs) large-scale vertical arrays. These AgNPs/GNRs arrays exhibit outstanding surface-enhanced Raman scattering (SERS) activities because of abundant Raman hot-spots among the adjacent AgNPs and GNRs, but also excellent stability and reproducibility due to the close-packed arrayed nanostructure. These remarkable features validate this arrayed substrate for high-sensitivity 4-aminothiophenol analysis with a detection limit of 0.35 pM and self-cleaning via electrochemical stripping of the adsorbed analytes and AgNPs from the GNRs arrays, therefore realizing renewable SERS applications. Moreover, the distinct SERS performance of AgNPs/GNRs arrays is verified via the analysis of multiplexed antibiotics at tens of picomolar level and no apparent changes of SERS activities are observed when recyclability is explored. The result demonstrates that the proposed AgNPs/GNRs arrays provide a novel strategy for avoiding conventional, disposable SERS substrates, as well as expanding SERS applications for simultaneous sensing and stripping of environmental contaminants.

中文翻译：

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等离子可调银包被的金纳米棒阵列作为可重复使用的SERS底物，用于多重抗生素检测

水性介质中的抗生素污染物对人类和生态环境构成了严重威胁。因此，有必要制定强有力的策略来检测抗生素残留。为此，采用了一种自组装和原位电化学还原方法来定制银纳米颗粒（AgNPs）涂层的GNR（AgNPs / GNRs）大规模垂直阵列。这些AgNPs / GNRs阵列由于相邻AgNPs和GNR之间的大量Ram​​an热点而表现出出色的表面增强拉曼散射（SERS）活动，而且由于紧密堆积的阵列纳米结构而具有出色的稳定性和可重复性。这些卓越的功能验证了该阵列基板可用于高灵敏度的4-氨基硫酚分析，检出限为0.35 pM，并通过电化学剥离GNRs阵列中吸附的分析物和AgNP，从而实现可再生SERS应用。此外，AgNPs / GNRs阵列的独特SERS性能通过数十皮摩尔水平的多重抗生素分析得到验证，并且在探索可回收性时未观察到SERS活性的明显变化。结果表明，提出的AgNPs / GNRs阵列为避免常规的一次性SERS基底提供了一种新颖的策略，并且扩展了SERS在同时感测和剥离环境污染物方面的应用。