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Combining Brachytherapy and Cryotherapy as Adjuvant Therapy for Squamous Cell Carcinoma of the Conjunctiva: Literature Review and Case Reports
Ocular Oncology and Pathology Pub Date : 2021-01-11 , DOI: 10.1159/000512029
Peter S Fagerberg 1 , Ingvild M S Ramberg 2 , Peter B Toft 1, 3
Affiliation  

Background: Separately, cryotherapy and brachytherapy have shown promising results when adjuvating the excision of squamous cell carcinoma of the conjunctiva (SCCC). The aim of this paper is to assess the combined effect in terms of complications and recurrence rate. Summary: We describe 2 patients suffering from SCCC, and we review the current literature on adjuvant cryotherapy and brachytherapy. Both patients, one of whom suffered from recurrent SCCC, underwent surgical excision followed by combined cryotherapy and brachytherapy. Cryotherapy was performed using a retinal cryoprobe, and 2 rounds each of 5 s with N2O as a cryogen were applied. Brachytherapy was performed using a ruthenium-106 plaque, delivering a dosage of 100 Gy at 2-mm depth. Key Messages: By reviewing the current literature and describing 2 case reports, this paper illustrates the use of combined cryotherapy and brachytherapy after surgical excision of SCCC. The current literature presents promising results of each treatment, and the 2 cases showed promising results by combining the 2 adjuvant therapies showing no signs of recurrence or complications during a follow-up period of 26 and 38 months.
Ocul Oncol Pathol


中文翻译:

结合近距离放射疗法和冷冻疗法作为结膜鳞状细胞癌的辅助疗法:文献回顾和病例报告

背景:在辅助结膜鳞状细胞癌 (SCCC) 切除术时,冷冻疗法和近距离放射疗法分别显示出可喜的结果。本文的目的是评估并发症和复发率方面的综合效果。摘要:我们描述了 2 名患有 SCCC 的患者,并回顾了当前关于辅助冷冻疗法和近距离放射疗法的文献。两名患者(其中一名患有复发性 SCCC)接受了手术切除,然后进行了冷冻疗法和近距离放射疗法的联合治疗。使用视网膜冷冻探针进行冷冻治疗,每次 5 秒进行 2 轮,使用 N 2 O 作为冷冻剂。使用钌 106 斑块进行近距离放射治疗,在 2 毫米深度提供 100 Gy 的剂量。关键信息:本文通过回顾现有文献并描述2例病例报告,阐述SCCC手术切除后联合冷冻和近距离放射治疗的应用。目前的文献介绍了每种治疗的有希望的结果,其中 2 例通过结合两种辅助疗法显示出有希望的结果,在 26 个月和 38 个月的随访期间没有复发或并发症的迹象。
眼肿瘤病理
更新日期:2021-01-11
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