Bacteriocins are antimicrobial peptides or proteinaceous materials produced by bacteria against pathogens. These molecules have high efficiency and specificity and are equipped with many properties useful in food-related applications, such as food preservatives and additives, as well as biomedical applications, such as serving as alternatives to current antibacterial, antiviral, anticancer, and antibiofilm agents. Despite their advantages as alternative therapeutics over existing strategies, several limitations of bacteriocins, such as the high cost of isolation and purification, narrow spectrum of activity, low stability and solubility, and easy enzymatic degradation, need to be improved. Nanomaterials are promising agents in many biological applications. They are widely used in the conjugation or decoration of bacteriocins to augment the activity of bacteriocins or reduce problems related to their use in biomedical applications. Therefore, bacteriocins combined with nanomaterials have emerged as promising molecules that can be used in various biomedical applications. This review highlights the features of bacteriocins and their limitations in biomedical applications and provides a detailed overview of the uses of different nanomaterials in improving the limitations. Our review focuses on the potential applications of nanomaterials combined with bacteriocins as new designer molecules for use in future therapeutic strategies.

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与细菌素结合的纳米材料在食品相关和生物医学方面的潜在新颖应用

细菌素是细菌针对病原体产生的抗菌肽或蛋白质物质。这些分子具有很高的效率和特异性，并具有许多可用于食品相关应用的特性，例如食品防腐剂和添加剂，以及生物医学应用，例如可作为当前抗菌剂，抗病毒剂，抗癌剂和抗生物膜剂的替代品。尽管它们比现有策略具有替代疗法的优势，但细菌素的一些局限性，例如分离和纯化的成本高，活性谱窄，稳定性和溶解性低以及容易酶促降解等，仍需要改善。纳米材料在许多生物学应用中是有前途的试剂。它们被广泛用于细菌素的缀合或修饰，以增加细菌素的活性或减少与其在生物医学应用中使用有关的问题。因此，细菌素与纳米材料的结合已经成为可以在各种生物医学应用中使用的有前途的分子。这篇综述重点介绍了细菌素的特性及其在生物医学应用中的局限性，并提供了不同纳米材料在改善局限性中用途的详细概述。我们的综述集中于与细菌素结合的纳米材料作为用于未来治疗策略的新型设计分子的潜在应用。细菌素与纳米材料的结合已经成为有希望的分子，可以用于各种生物医学应用中。这篇综述重点介绍了细菌素的特性及其在生物医学应用中的局限性，并提供了不同纳米材料在改善局限性中用途的详细概述。我们的综述集中于与细菌素结合的纳米材料作为新的设计分子的潜在应用，以用于未来的治疗策略。细菌素与纳米材料的结合已经成为有前途的分子，可以用于各种生物医学应用中。这篇综述重点介绍了细菌素的特性及其在生物医学应用中的局限性，并提供了不同纳米材料在改善局限性中用途的详细概述。我们的综述集中于与细菌素结合的纳米材料作为用于未来治疗策略的新型设计分子的潜在应用。