Abstract

The loss and overuse of avermectin (AVM) on protecting plants pose a threat to ecosystems. To increase the efficacy of AVM, fluorinated sodium carboxymethyl cellulose (CMC-g-PHFBA) was synthesized by inducing poly 2, 2, 3, 4, 4, 4-hexafluorobutyl methacrylate (HFBA), and AVM was then enveloped in CMC-g-PHFBA (AVM@CMC-g-PHFBA) via hydrophobic interaction. According to the results, the samples exhibited desirable angle contact (min = 58.18°), retention rate (max = 60%, after water washing) and LHC (15.5 mg/cm²) on cucumber leaves. AVM@CMC-g-PHFBA also showed good storage stability with obvious Tyndall effect (size <240 nm and charge <–21 mV) for 11 days, with higher anti-UV property. The loaded AVM nanoparticles can release drugs for 95 h, which can be fitted to a zero-order model under different pH conditions for achieving a prolonged pharmacological action. Moreover, the samples have retained insecticidal activity. Collectively, CMC-g-PHFBA nanoparticles are promising delivery systems of AVM with the adhesive and sustained-release property.

摘要

阿维菌素（AVM）在保护植物上的损失和过度使用对生态系统构成了威胁。为了提高AVM的功效，通过诱导聚2，2，3，4，4，4，甲基丙烯酸六氟丁酯（HFBA）合成了氟化羧甲基纤维素钠（CMC-g-PHFBA），然后将AVM包裹在CMC-g中-PHFBA（AVM @ CMC-g-PHFBA）通过疏水相互作用。根据结果​​，样品显示出理想的角接触（最小= 58.18°），保留率（最大= 60％，水洗后）和LHC（15.5 mg / cm ^2））放在黄瓜叶上。AVM @ CMC-g-PHFBA还显示出良好的储存稳定性，并具有明显的丁达尔效应（尺寸<240 nm，电荷<–21 mV）11天，具有更高的抗紫外线性能。负载的AVM纳米颗粒可以释放95小时的药物，可以在不同的pH条件下将其拟合为零级模型，以实现延长的药理作用。而且，样品保留了杀虫活性。总的来说，CMC-g-PHFBA纳米粒子是具有粘性和持续释放特性的AVM的有前途的传递系统。