Abstract

Introduction

Vaccine delivery via a microneedle (MN) system has been identified as a potential alternative to conventional vaccine delivery. MN can be self-administered, is pain free and is capable of producing superior immunogenicity. Over the last few decades, significant research has been carried out in this area, and this review aims to provide a comprehensive picture on the progress of this delivery platform.

Areas covered

This review highlights the potential role of skin as a vaccine delivery route using a microneedle system, examines recent advancements in microneedle fabrication techniques and provides an update on potential preclinical and clinical studies on vaccine delivery through microneedle systems against various infectious diseases. Articles for the review study were searched electronically in PubMed, Google, Google Scholar and Science Direct using specific keywords to cover the scope of the article. The advanced search strategy was employed to identify the most relevant articles.

Expert opinion

A significant number of MN mediated vaccine candidates have shown promising results in preclinical and clinical trials. The recent emergence of cleanroom free, 3D or additive manufacturing of MN systems and stability, together with the dose sparing capacity of the Nanopatch® system, have made this platform, commercially, highly lucrative.

中文翻译：

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用于疫苗接种的微针系统：到目前为止的故事

摘要

介绍

通过微针（MN）系统进行疫苗输送已被确定为常规疫苗输送的潜在替代方法。MN可以自我给药，无疼痛且能够产生卓越的免疫原性。在过去的几十年中，已经在这一领域进行了重要的研究，并且本次审查旨在提供有关该交付平台的进展情况的全面介绍。

覆盖区域

这篇综述强调了皮肤作为使用微针系统的疫苗输送途径的潜在作用，研究了微针制造技术的最新进展，并提供了有关通过微针系统针对各种传染性疾病进行疫苗输送的潜在临床前和临床研究的最新信息。使用特定关键字在PubMed，Google，Google Scholar和Science Direct中以电子方式搜索了评价研究的文章，以涵盖文章的范围。高级搜索策略被用来识别最相关的文章。

专家意见

在临床前和临床试验中，大量的MN介导的候选疫苗已显示出令人鼓舞的结果。MN系统的无尘室，3D或增材制造的最新出现和稳定性以及Nanopatch®系统的剂量节省能力，使得该平台在商业上非常有利可图。