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Enantioselective conjugate addition of pyrazolones to nitroalkenes catalyzed by chiral squaramide organocatalyst
Chirality ( IF 2 ) Pub Date : 2021-01-11 , DOI: 10.1002/chir.23295
Alime Ebru Aydin 1 , Selda Culha 1
Affiliation  

The chiral squaramide catalysts (8–15) were synthesized, and their catalytic efficiency in the enantioselective conjugate addition of pyrazolones to nitroalkenes was described. This protocol provides excellent chemical yields (up to 93%) of chiral 5‐methyl‐4‐(2‐nitro‐1‐arylethyl)pyrazol‐3‐ol derivatives with high enantioselectivities (up to 97% ee).

中文翻译:

手性方酰胺有机催化剂催化吡咯烷酮向硝基烯烃的对映选择性共轭加成反应

合成了手性方酰胺催化剂(8-15),并描述了它们在吡唑酮对硝基烯烃的对映选择性共轭加成中的催化效率。该方案可提供具有高对映选择性(高达97%ee)的手性5-甲基-4-(2-硝基-1-芳基乙基)吡唑-3-醇衍生物,化学产率高(高达93%)。
更新日期:2021-02-10
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