A dual diaminopyrrolidine based peptide nucleic acid (dapPNA) monomer that give rise to two different PNA backbones (shown in blue & red) was synthesized using orthogonal solid phase chemistry. Presence of free amino group makes PNA cationic and thus not only show high thermal stability in complexation with DNA but also overcomes the unfavorable stereochemical effects.

中文翻译：

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静电学偏爱PNA：基于吡咯烷的阳离子双主干PNA类似物的DNA稳定性优于立体化学

使用正交固相化学合成了基于双二氨基吡咯烷的肽核酸（dap PNA）单体，该单体产生两个不同的PNA主链（以蓝色和红色显示）。游离氨基的存在使PNA成为阳离子，因此不仅与DNA结合显示出高的热稳定性，而且还克服了不利的立体化学作用。