Synthesis of 25X-BOMes and 25X-NBOHs (X = H, I, Br) for pharmacological studies and as reference standards for forensic purposes,Tetrahedron Letters

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Synthesis of 25X-BOMes and 25X-NBOHs (X = H, I, Br) for pharmacological studies and as reference standards for forensic purposes
Tetrahedron Letters ( IF 1.8 ) Pub Date : 2021-01-11 , DOI: 10.1016/j.tetlet.2020.152804
Wellington Alves de Barros , Marcelo Pereira Queiroz , Leonardo da Silva Neto , Graziele Martins Borges , Felipe Terra Martins , Ângelo de Fátima

An expeditious method is reported for the synthesis of three NBOHs (25H-, 25I- and 25B-NBOH; 9–38% overall yield) and three NBOMes (25H-, 25I- and 25B-NBOMe; 7–33% overall yield) from salicylaldehyde and 2-methoxyaldehyde, respectively. The X-ray structures of 25H-, 25I- and 25B-NBOH.HCl were also determined. Our approach should provide a general entry for preparing such a class of substances for pharmacological and forensic purposes.

中文翻译：

25X-BOMes和25X-NBOHs（X = H，I，Br）的合成，用于药理研究和作为法医参考标准

据报道，一种快速方法可合成三种NBOH（25H-，25I-和25B-NBOH；总产率为9–38％）和三种NBOM（25H-，25I-和25B-NBOMe；总产率为7–33％）。分别来自水杨醛和2-甲氧基醛。还确定了25H-，25I-和25B-NBOH.HCl的X射线结构。我们的方法应该为制备用于药理学和法医学目的的这类物质提供一个一般的入口。

更新日期：2021-02-26

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