Mitragynine is the main alkaloid isolated from the leaves of Mitragyna speciosa Korth (Kratom). Kratom has been widely used to relieve pain and opioid withdrawal symptoms in humans but may also cause memory deficits. Here we investigated the changes in brain electroencephalogram (EEG) activity after acute and chronic exposure to mitragynine in freely moving rats. Vehicle, morphine (5 mg/kg) or mitragynine (1, 5 and 10 mg/kg) were administered for 28 days, and EEG activity was repeatedly recorded from the frontal cortex, neocortex and hippocampus. Repeated exposure to mitragynine increased delta, but decreased alpha powers in both cortical regions. It further decreased delta power in the hippocampus. These findings suggest that acute and chronic mitragynine can have profound effects on EEG activity, which may underlie effects on behavioral activity and cognition, particularly learning and memory function.

Mitragynine是从Mitragyna speciosa叶子中分离的主要生物碱科尔斯（Kratom）。Kratom已被广泛用于缓解人的疼痛和阿片类药物戒断症状，​​但也可能导致记忆缺陷。在这里，我们研究了自由活动大鼠急性和慢性暴露于米他宁后脑电图（EEG）活动的变化。施用媒介物吗啡（5 mg / kg）或米他宁（1、5和10 mg / kg）28天，并从额叶皮层，新皮层和海马中反复记录EEG活性。反复暴露于米塔吉宁会增加δ，但会降低两个皮质区域的α功效。它进一步降低了海马体的三角洲能力。这些发现表明，急性和慢性米他宁可对脑电活动产生深远影响，这可能是对行为活动和认知，特别是学习和记忆功能的影响。