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The primitive interferon-like system and its antiviral function in molluscs
Developmental & Comparative Immunology ( IF 2.9 ) Pub Date : 2021-01-11 , DOI: 10.1016/j.dci.2021.103997
Xue Qiao 1 , Lingling Wang 2 , Linsheng Song 2
Affiliation  

The phylum mollusca is a very important group in the animal kingdom for the large number and diversified species. Recently, interest in molluscan immunity has increased due to their phylogenetic position and importance in worldwide aquaculture and aquatic environment. As the main aquaculture animal, most molluscs live in the water environment and they have to cope with many pathogen challenges, in which virus is one of the primary causes for the mass mortality. In vertebrates, interferon (IFN) system is generally recognized as the first line of defence against viral infection, while the antiviral mechanisms in molluscs remain to be clearly illuminated. Recently, some IFN-like proteins and IFN-related components have been characterized from molluscs, such as pattern recognition receptors (PRRs), interferon regulatory factors (IRFs), IFN-like receptors, JAK/STAT and IFN-stimulated genes (ISGs), which reinforce the existence of IFN-like system in molluscs. This system can be activated by virus or poly (I:C) challenges and further regulate the antiviral response of haemocytes in molluscs. This review summarizes the research progresses of IFN-like system in molluscs with the emphases on the uniformity and heterogeneity of IFN-like system of molluscs compared to that of other animals, which will be helpful for elucidating the antiviral modulation in molluscs and understanding the origin and evolution of IFN system.



中文翻译:

原始干扰素样系统及其在软体动物中的抗病毒作用

软体动物门是动物界非常重要的群体,种类繁多,种类繁多。最近,由于软体动物的系统发育位置和在全球水产养殖和水生环境中的重要性,人们对软体动物免疫的兴趣有所增加。作为主要的水产养殖动物,大多数软体动物生活在水环境中,它们必须应对许多病原体挑战,其中病毒是导致大量死亡的主要原因之一。在脊椎动物中,干扰素 (IFN) 系统通常被认为是抵御病毒感染的第一道防线,而软体动物的抗病毒机制仍有待明确阐明。最近,一些 IFN 样蛋白和 IFN 相关成分已从软体动物中表征,例如模式识别受体 (PRR)、干扰素调节因子 (IRF)、干扰素样受体、JAK/STAT 和干扰素刺激基因 (ISG),它们加强了软体动物中干扰素样系统的存在。该系统可以被病毒或聚 (I:C) 攻击激活,并进一步调节软体动物血细胞的抗病毒反应。本综述总结了软体动物类干扰素系统的研究进展,重点介绍了软体动物类干扰素系统与其他动物相比的均一性和异质性,有助于阐明软体动物的抗病毒调控机制和了解其起源。和干扰素系统的演变。

更新日期:2021-01-18
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