Because of resistance to bio-macromolecular adhesion, antifouling hydrogels have attracted great attention in biomedical field. But traditional antifouling hydrogels made by hydrophilic polymers are always poor of mechanical properties. Herein, a new hybrid ionic-covalent cross-linked double network (DN) hydrogel was prepared by a simple one-pot method based on sodium alginate and the zwitterionic material carboxybetaine acrylamide (CBAA). The DN hydrogel has good mechanical properties, including high elastic modulus (0.28 MPa), high tensile strength (0.69 MPa), as well as good self-recovery capability. More importantly, the DN hydrogel is highly resistance to the adsorption of non-specific protein, cells, bacteria and algae, exhibiting an outstanding antifouling property. The in vitro and in vivo experiments prove that the DN hydrogel is highly biocompatible. This study provides a new strategy for the preparation of antifouling DN hydrogels with good mechanical properties for different needs, such as tissue scaffolds, wound dressings, implantable devices, and other fields.

由于抗生物大分子粘附，防污水凝胶在生物医学领域引起了极大的关注。但是，由亲水性聚合物制成的传统防污水凝胶的机械性能始终较差。在此，基于藻酸钠和两性离子材料羧基甜菜碱丙烯酰胺（CBAA），通过简单的一锅法制备了一种新型的杂化的离子共价交联双网络（DN）杂化水凝胶。DN水凝胶具有良好的机械性能，包括高弹性模量（0.28 MPa），高拉伸强度（0.69 MPa）以及良好的自我恢复能力。更重要的是，DN水凝胶对非特异性蛋白质，细胞，细菌和藻类的吸附具有很高的抵抗力，表现出出色的防污性能。在体外和体内实验证明DN水凝胶具有高度的生物相容性。这项研究为制备具有良好机械性能的防污DN水凝胶提供了新的策略，以满足不同需求，例如组织支架，伤口敷料，可植入设备以及其他领域。