The role of dopaminergic transmission in the mechanism of analgesic action of the low-affinity NMDAreceptor antagonist hemantane [ N -(2-adamantyl)hexamethyleneimine hydrochloride] was demonstrated experimentally. A single i.p. injection of hemantane at a dose of 20 mg/kg has the ability to inhibit dopamine reuptake and exhibits an analgesic effect in the somatic thermal pain model (tail-flick test) and visceral pain model (acetic-acid-induced writhing test) in ICR mice. The dopamine D1 receptor antagonist R(+)-SCH-23390 at a dose of 0.005 mg/kg and dopamine D2 receptor antagonist sulpiride at a dose of 5 mg/kg administered by a single i.p. injection 30 min before hemantane injection prevented manifestation of the antinociceptive activity of the NMDA receptor antagonist in the used methods, which was more pronounced for the spinal reflex (tail-flick test).

中文翻译：

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多巴胺能成分在低亲和力 NMDA 受体拮抗剂 Hemantane 镇痛作用中的作用

实验证明了多巴胺能传递在低亲和力 NMDA 受体拮抗剂庚烷 [N -(2-金刚烷基)六亚甲基亚胺盐酸盐]的镇痛作用机制中的作用。单次 ip 注射剂量为 20 mg/kg 的庚烷具有抑制多巴胺再摄取的能力，并在躯体热痛模型（甩尾试验）和内脏痛模型（醋酸诱导扭体试验）中表现出镇痛作用) 在 ICR 小鼠中。剂量为 0.005 mg/kg 的多巴胺 D1 受体拮抗剂 R(+)-SCH-23390 和剂量为 5 mg/kg 的多巴胺 D2 受体拮抗剂舒必利在注射庚烷前 30 分钟通过单次 ip 注射给药，可防止出现NMDA受体拮抗剂在所用方法中的镇痛活性，