Abstract

A series of 1,3-disubstituted ureas containing a bicyclic lipophilic group of natural origin were synthesized by the reactions of bicyclo[2.2.1]heptane-2-yl isocyanate with amines in yields of up to 82% and by the reactions of bicyclo[2.2.1]heptan-2-amine and 1,7,7-trimethylbicyclo[2.2.1]heptan-2-amine with 1,1'-carbonyldiimidazole in yields of up to 94%. The synthesized ureas are potent inhibitors of RNA virus replication and soluble epoxide hydrolase.

中文翻译：

---

含多环片段的1,3-二取代尿素及其等位类似物的合成与性质：V. 1-（双环[2.2.1]庚-2-基）-3-R-和1-（1,7,7-三环[2.2.1]庚-2-基）-3-R-脲

摘要

通过双环[2.2.1]庚烷-2-基异氰酸酯与胺的反应，合成产率最高为82％的一系列含有天然双环亲脂性基团的1,3-二取代脲，并通过双环反应[2.2.1]庚-2-胺和1,7,7-三甲基双环[2.2.1]庚-2-胺与1,1'-羰基二咪唑的产率高达94％。合成的脲是RNA病毒复制和可溶性环氧化物水解酶的有效抑制剂。