Aflatoxin (AF) contamination of food products is still a major health issue globally. Prior studies suggest that exposure to AFs during pregnancy has harmful fetal outcomes. This preliminary study was designed to assess serum AFB₁ levels in neonatal jaundice (NNJ) secondary to glucose-6-phosphate dehydrogenase (G6PD) deficiency. Twenty-four full-term neonates with hemolytic jaundice secondary to G6PD deficiency were enrolled in the study. Erythrocyte G6PD status was assessed colorimetrically, and serum aflatoxin B₁ (AFB₁) concentrations were measured by high-performance liquid chromatography. The results revealed that AFB₁ was detected in 58% (14/24) of the studied newborns while detected in 75% (18/24) of their mothers. AFB₁ positive cases had a highly significantly lower birthweight and G6PD activity (P = 0.001, each). Birthweight (r = − 0.574, P = 0.032) and G6PD activity (r = − 0.585, P = 0.028) negatively correlated with serum AFB₁ levels while serum alanine aminotransferase activity positively correlated with serum AFB₁ levels (r = 0.536, P = 0.048). Maternal AFB₁ exposure is associated with adverse birth outcomes as verified by the low birthweight and the evident decline in the activity of G6PD enzyme with the resultant hemolytic NNJ.

食品中的黄曲霉毒素 (AF) 污染仍然是全球主要的健康问题。先前的研究表明，怀孕期间接触 AF 会对胎儿产生有害的结果。这项初步研究旨在评估继发于葡萄糖 6-磷酸脱氢酶 (G6PD) 缺乏症的新生儿黄疸 (NNJ) 中的血清 AFB ₁水平。24 名患有 G6PD 缺乏症继发溶血性黄疸的足月新生儿参加了这项研究。通过比色法评估红细胞 G6PD 状态，并通过高效液相色谱法测量血清黄曲霉毒素 B ₁ (AFB ₁ ) 浓度。结果显示，在 58% (14/24) 的研究新生儿中检测到AFB ₁，而在 75% (18/24) 的母亲中检测到AFB ₁。空军基地₁例阳性病例的出生体重和 G6PD 活性显着降低（P  = 0.001，各）。出生体重 ( r  = − 0.574, P  = 0.032) 和 G6PD 活性 ( r  = − 0.585, P  = 0.028) 与血清 AFB ₁水平呈负相关，而血清丙氨酸转氨酶活性与血清 AFB ₁水平呈正相关( r  = 0.536, P  = 0.048）。母体 AFB ₁暴露与不良出生结果相关，这一点通过低出生体重和 G6PD 酶活性明显下降以及由此产生的溶血性 NNJ 得到证实。