DNA replication checkpoint is a cell signaling pathway that is activated in response to perturbed replication. Although it is crucial for maintaining genomic integrity and cell survival, the exact mechanism of the checkpoint signaling remains to be understood. Emerging evidence has shown that RecQ helicases, a large family of helicases that are conserved from bacteria to yeasts and humans, contribute to the replication checkpoint as sensors, adaptors, or regulation targets. Here, we highlight the multiple functions of RecQ helicases in the replication checkpoint in four model organisms and present additional evidence that fission yeast RecQ helicase Rqh1 may participate in the replication checkpoint as a sensor.

DNA 复制检查点是一种细胞信号通路，它响应受干扰的复制而被激活。尽管它对于维持基因组完整性和细胞存活至关重要，但检查点信号传导的确切机制仍有待了解。新出现的证据表明，RecQ 解旋酶是从细菌到酵母菌和人类中保守的一大类解旋酶，作为传感器、适配器或调节目标有助于复制检查点。在这里，我们强调了 RecQ 解旋酶在四种模式生物的复制检查点中的多种功能，并提供了额外的证据表明裂殖酵母 RecQ 解旋酶 Rqh1 可能作为传感器参与复制检查点。