For a long time, the pharmaceutical industry focused on natural biologically active molecules due to their unique properties, availability and significantly less side-effects. Mangiferin is a naturally occurring C-glucosylxantone that has substantial potential for the treatment of various diseases thanks to its numerous biological activities. Many research studies have proven that mangiferin possesses antioxidant, anti-infection, anti-cancer, anti-diabetic, cardiovascular, neuroprotective properties and it also increases immunity. It is especially important that it has no toxicity. However, mangiferin is not being currently applied to clinical use because its oral bioavailability as well as its absorption in the body are too low. To improve the solubility, enhance the biological action and bioavailability, mangiferin integrated polymer systems have been developed. In this paper, we review molecular mechanisms of anti-cancer action as well as a number of designed polymer-mangiferin systems. Taking together, mangiferin is a very promising anti-cancer molecule with excellent properties and the absence of toxicity.

中文翻译：

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芒果苷作为新型潜在抗癌剂和芒果苷集成聚合物体系——一个新的研究方向

长期以来，制药行业一直关注天然生物活性分子，因为它们具有独特的性质、可用性和显着减少的副作用。芒果苷是一种天然存在的 C-葡萄糖基黄酮，由于其众多的生物活性，具有治疗各种疾病的巨大潜力。许多研究证明，芒果苷具有抗氧化、抗感染、抗癌、抗糖尿病、心血管、神经保护特性，还可以增强免疫力。尤其重要的是它没有毒性。但由于芒果苷的口服生物利用度和体内吸收率均较低，目前尚未应用于临床。为了提高溶解度、增强生物作用和生物利用度，人们开发了芒果苷集成聚合物系统。在本文中，我们回顾了抗癌作用的分子机制以及一些设计的聚合物芒果苷系统。综上所述，芒果苷是一种非常有前途的抗癌分子，具有优异的性能且无毒性。