The surface receptor for advanced glycosylation end-products (RAGE) and its soluble (sRAGE) and endogenous secretory (EN-RAGE) forms belong to the superfamily of toll-like receptors and play important roles in inflammation and autoimmunity, directly or through binding with advanced glycosylation end-products (AGE) and advanced oxidation protein products (AOPP). We reviewed the literature on the role of RAGE in skin diseases. Research in this field is still rather limited (28 articles) but suggests the involvement of RAGE and RAGE-related pathways in chronic inflammatory diseases (lupus, psoriasis, atopic dermatitis, and lichen planus), infectious diseases (leprosy, Staphylococcus aureus-induced skin lesions), alterations of the repairing processes in diabetic skin, systemic sclerosis, and ulcers. These data prompt further research in this field, which not only will be useful to better understand the pathogenetic mechanisms of diseases, but is also likely to have intriguing clinical implications. Indeed, when their role in the complex and multifactorial inflammatory balance will be adequately defined, RAGE and related molecules could be used as markers of disease severity and/or response to treatment. Moreover, future promising therapeutic perspectives could be topical administration of some of these molecules (e.g., sRAGE) to modulate local inflammatory response and/or the development of anti-RAGE antibodies for systemic treatment.

中文翻译：

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RAGE和氧化应激与炎性和感染性皮肤病的关系

高级糖基化终产物（RAGE）及其可溶性（sRAGE）和内源性分泌（EN-RAGE）形式的表面受体属于toll-like受体的超家族，在炎症和自身免疫中直接或通过与之结合起重要作用。先进的糖基化终产物（AGE）和先进的氧化蛋白产物（AOPP）。我们回顾了有关RAGE在皮肤疾病中的作用的文献。该领域的研究仍然相当有限（28篇文章），但表明RAGE和RAGE相关途径参与了慢性炎性疾病（狼疮，牛皮癣，特应性皮炎和扁平苔藓），传染病（麻风，金黄色葡萄球菌）-诱导的皮肤损伤），糖尿病皮肤修复过程的改变，全身性硬化症和溃疡。这些数据促进了该领域的进一步研究，这不仅有助于更好地了解疾病的致病机制，而且还可能具有令人感兴趣的临床意义。确实，当将充分定义其在复杂和多因素炎症平衡中的作用时，RAGE和相关分子可以用作疾病严重性和/或对治疗反应的标志物。而且，未来有希望的治疗观点可以是局部施用这些分子中的一些（例如sRAGE）以调节局部炎症反应和/或开发用于全身治疗的抗RAGE抗体。