Staphylococcus aureus (S. aureus) is a major cause of infectious disease. Macrophages can directly destroy most of the invading bacteria through the phagolysosomal pathway. E74-like factor 4 (Elf4) is one of the important transcription factors that controls diverse pathogens, but the role of Elf4 in macrophage-mediated S. aureus eradication is unknown. Our data show that Elf4 is induced by S. aureus in macrophages. Elevated expression of Elf4 results in decreased bacterial load and inflammatory responses during S. aureus infection in vivo and in vitro. Elf4-overexpressed macrophages have decreased mTOR activity and increased lysosomal mass. Collectively, these results suggest that S. aureus induces Elf4 expression, which enhances lysosomal function and increases the capacity of macrophages to eliminate intracellular pathogens.

中文翻译：

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Elf4 调节溶酶体生物发生和 mTOR 通路以促进巨噬细胞中金黄色葡萄球菌的清除

金黄色葡萄球菌（S. aureus）是传染病的主要原因。巨噬细胞可以通过吞噬溶酶体途径直接消灭大部分入侵细菌。E74 样因子 4 (Elf4) 是控制多种病原体的重要转录因子之一，但 Elf4 在巨噬细胞介导的金黄色葡萄球菌根除中的作用尚不清楚。我们的数据显示 Elf4 是由巨噬细胞中的金黄色葡萄球菌诱导的。Elf4 的表达升高导致体内和体外金黄色葡萄球菌感染期间细菌负荷和炎症反应降低。Elf4 过表达的巨噬细胞降低了 mTOR 活性并增加了溶酶体质量。总的来说，这些结果表明金黄色葡萄球菌诱导 Elf4 表达，从而增强溶酶体功能并增加巨噬细胞消除细胞内病原体的能力。