Cellular heterogeneity is an important biological phenomenon observed across space and time in human tissues. Imaging-based spatial proteomic technologies can provide fruitful new readouts of phenotypic states for individual cells at subcellular resolution, which may help unravel the roles of non-genetic cellular heterogeneity in tumorigenesis and drug resistance.

中文翻译：

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用基于成像的空间蛋白质组学阐明非遗传细胞异质性

细胞异质性是在人体组织中跨空间和时间观察到的重要生物学现象。基于成像的空间蛋白质组学技术可以在亚细胞分辨率下为单个细胞提供富有成效的新表型状态读数，这可能有助于阐明非遗传细胞异质性在肿瘤发生和耐药性中的作用。