Previous reports suggested that non-dioxin-like (NDL) PCB153 effects on cytochrome P450 3A (Cyp3a) expression in Atlantic killifish (Fundulus heteroclitus) gills differed between F0 generation fish from a PCB site (New Bedford Harbor; NBH) and a reference site (Scorton Creek; SC). Here, we examined effects of PCB153, dioxin-like (DL) PCB126, or a mixture of both, on Cyp3a56 mRNA in killifish generations removed from the wild, without environmental PCB exposures. PCB126 effects in liver and gills differed between populations, as expected. Gill Cyp3a56 was not affected by either congener in NBH F2 generation fish, but was induced by PCB153 in SC F1 fish, with females showing a greater response. PCB153 did not affect Cyp3a56 in liver of either population. Results suggest a heritable resistance to NDL-PCBs in killifish from NBH, in addition to that reported for DL PCBs. Induction of Cyp3a56 in gills may be a biomarker of exposure to NDL PCBs in fish populations that are not resistant to PCBs.

以前的报告表明，非二恶英样 (NDL) PCB153 对大西洋鳉鱼( Fundulus heteroclitus ) 鳃中细胞色素 P450 3A ( Cyp3a ) 表达的影响在来自 PCB 站点（新贝德福德港；NBH）和参考站点的 F0 代鱼之间有所不同（斯科顿溪；SC）。在这里，我们检查了 PCB153、二恶英样 (DL) PCB126 或两者的混合物对从野生环境中移除的鳉鱼世代中Cyp3a56 mRNA 的影响，而没有环境 PCB 暴露。正如预期的那样，PCB126 对肝脏和鳃的影响在不同人群中有所不同。Gill Cyp3a56在 NBH F2 代鱼中不受任一同源物的影响，但在 SC F1 鱼中受 PCB153 诱导，雌性表现出更大的反应。PCB153没有影响Cyp3a56在任一人群的肝脏中。结果表明，除了 DL PCB 的报道外，来自 NBH 的鳉鱼对 NDL-PCB 具有可遗传的抗性。鳃中Cyp3a56 的诱导可能是对多氯联苯不具有抗性的鱼类种群中暴露于 NDL 多氯联苯的生物标志物。