No to less effort has been made to assess the toxicity of silver nanoparticles (AgNPs) to lipid composition in biological systems and also to discover a mitigating agent against their oxidative stress. Hence, this research evaluated the antioxidant capability of quercetin (Qu) against silver nanoparticles (AgNPs) toxicity towards the lipid contents of ovarian, nervous, and hepatic systems as well as skeletal muscles. To this end, zebrafish (n = 180) were assigned into four experimental dietary groups: negative and positive controls, without Qu supplementation; Qu-200, 200 mg Qu per kg diet; and Qu-400, 400 mg Qu per kg diet. At the end of the feeding trial (40 days), the experimental groups, except the negative control, were exposed to sublethal concentration of AgNPs (0.15 mg L⁻¹) for 96 h. As to the liver tissue of the positive and Qu-200 treatments, total polyunsaturated fatty acids (∑PUFA) decreased 3 times, as well as total high unsaturated fatty acids (∑HUFA) reduced about 30% and 50%, respectively. However, the brain ∑HUFA, predominated by DHA, enhanced in Qu-400 treatment. Interestingly, ∑MUFA, ∑PUFA, and ∑HUFA increased in the muscle of all treated groups, especially Qu-200 and Qu-400. The oocyte ∑MUFA content increased in the positive and Qu-200 treatments, whereas ∑HUFA reduced about 25%, 25%, and 20%, respectively, in the positive, Qu-200, and Qu-400 groups. Generally, the findings suggest that unsaturated acyl chains, particularly HUFAs, in the liver tissue and oocyte cell are highly susceptible to peroxidation or degeneration by AgNPs. More broadly, in the context of ecotoxicological risk assessment, the alteration in HUFAs and PUFAs of the liver and oocyte could impact on maternal and offspring health and consequently alter long-term population dynamics of aquatic animals.

做出了不懈的努力来评估银纳米颗粒（AgNP）对生物系统中脂质成分的毒性，并发现减轻其氧化应激的缓解剂。因此，这项研究评估了槲皮素（Qu）对银纳米颗粒（AgNPs）对卵巢，神经和肝系统以及骨骼肌脂质含量的毒性的抗氧化能力。为此，将斑马鱼（n = 180）分为四个实验饮食组：阴性和阳性对照组，不添加Qu。Qu-200，每公斤饮食200 mg Qu; Qu-400，每公斤饮食400 mg Qu。在喂养试验结束时（40天），除阴性对照组外，实验组均暴露于亚致死浓度的AgNPs（0.15 mg L ^-1）96小时。对于阳性和Qu-200处理的肝组织，总多不饱和脂肪酸（∑PUFA）减少了3倍，总高不饱和脂肪酸（∑HUFA）分别减少了约30％和50％。然而，以DHA为主的大脑∑HUFA在Qu-400治疗中得到了增强。有趣的是，所有治疗组，尤其是Qu-200和Qu-400的肌肉中∑MUFA，∑PUFA和∑HUFA均增加。阳性和Qu-200处理的卵母细胞∑MUFA含量增加，而阳性，Qu-200和Qu-400处理的∑HUFA分别降低约25％，25％和20％。通常，这些发现表明，肝组织和卵母细胞中的不饱和酰基链，特别是HUFA对AgNPs过氧化或变性高度敏感。更广泛地说，在生态毒理学风险评估的背景下，