DNA Repair ( IF 3.8 ) Pub Date : 2021-01-09 , DOI: 10.1016/j.dnarep.2021.103047 Fatemeh Sadoughi 1 , Jamal Hallajzadeh 2 , Zatollah Asemi 1 , Mohammad Ali Mansournia 3 , Forough Alemi 4 , Bahman Yousefi 5
Our genome bears tens of thousands of harms and devastations per day; In this regard, numerous sophisticated and complicated mechanisms are embedded by our cells in furtherance of remitting an unchanged and stable genome to their next generation. These mechanisms, that are collectively called DDR, have the duty of detecting the lesions and repairing them. it’s necessary for the viability of any living cell that sustain the integrity and stability of its genetic content and this highlights the role of mediators that transduce the signals of DNA damage to the cell cycle in order to prevent the replication of a defective DNA. In this paper, we review the signaling pathways that lie between these processes and define how different ingredients of DDR are also able to affect the checkpoint signaling.
中文翻译:
DNA断裂期间参与细胞周期停滞的信号通路
我们的基因组每天承受数以万计的伤害和破坏;在这方面,我们的细胞嵌入了许多复杂的机制,以促进将未改变和稳定的基因组传递给下一代。这些机制统称为 DDR,负责检测病变并修复它们。任何活细胞的生存能力都需要维持其遗传内容的完整性和稳定性,这突出了将 DNA 损伤信号转导到细胞周期以防止有缺陷 DNA 复制的介质的作用。在本文中,我们回顾了这些过程之间的信号通路,并定义了 DDR 的不同成分如何影响检查点信号。