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Observing antimicrobial process with traceable gold nanoclusters
Nano Research ( IF 9.9 ) Pub Date : 2020-11-15 , DOI: 10.1007/s12274-020-3146-5
Kaiyuan Zheng , Magdiel I. Setyawati , David Tai Leong , Jianping Xie

Understanding the interaction of nanomaterials with biological systems has always been of high concern and interest. An emerging type of nanomaterials, ultrasmall metal nanoclusters (NCs, < 2 nm in size), are promising in this aspect due to their well-defined molecular formulae and structures, as well as unique physical and chemical properties that are distinctly different from their larger counterparts (metal nanoparticles). For example, metal NCs possess intrinsic strong luminescence, which can be used for real-time tracking of their interactions with biological systems. Herein, luminescent gold (Au) NCs were used as traceable antimicrobial agents to study their interactions with the bacteria and to further understand their underlining antimicrobial mechanism. It is shown for the first time that the Au NCs would first attach on the bacterial membrane, penetrate, and subsequently accumulate inside the bacteria. Thereafter, the internalized Au NCs would induce reactive oxygen species (ROS) generation and damage the bacterial membrane, resulting in the leakage of bacterial contents, which can finally kill the bacteria. Traceable Au NCs (or other metal NCs) provide a promising platform to study the antimicrobial mechanisms as well as other fundamentals on the interfacing of functional nanomaterials with the biological systems, further increasing their acceptance in various biomedical applications.



中文翻译:

用可追踪的金纳米团簇观察抗菌过程

一直以来,了解纳米材料与生物系统的相互作用一直是人们高度关注和关注的问题。超小型金属纳米团簇(NC,尺寸<2 nm)是一种新兴的纳米材料,由于其定义明确的分子式和结构以及独特的物理和化学性质(与较大的纳米团明显不同)而在这一方面很有前途对应物(金属纳米粒子)。例如,金属NC具有固有的强发光特性,可用于实时跟踪其与生物系统的相互作用。在这里,发光金(Au)NCs被用作可追溯的抗菌剂,以研究它们与细菌的相互作用并进一步了解其强调的抗菌机理。首次表明,金纳米管将首先附着在细菌膜上,渗透并随后在细菌内部积累。此后,内在化的Au NCs将诱导活性氧(ROS)生成并破坏细菌膜,导致细菌内含物泄漏,最终杀死细菌。可追溯的Au NCs(或其他金属NCs)提供了一个有前途的平台,用于研究功能性纳米材料与生物系统之间的抗微生物机制以及其他基础,从而进一步提高了它们在各种生物医学应用中的接受度。导致细菌内含物的泄漏,最终可以杀死细菌。可追溯的Au NCs(或其他金属NCs)提供了一个有前途的平台,用于研究功能性纳米材料与生物系统之间的抗微生物机制以及其他基础,从而进一步提高了它们在各种生物医学应用中的接受度。导致细菌内含物的泄漏,最终可以杀死细菌。可追溯的Au NCs(或其他金属NCs)提供了一个有前途的平台,用于研究功能性纳米材料与生物系统之间的抗微生物机制以及其他基础,从而进一步提高了它们在各种生物医学应用中的接受度。

更新日期:2021-01-10
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