Abstract

In the recent decade, the study on N-heterocycles has dramatically increased due to its versatility in many significant fields and because of its distinctive battle which is associated with the bioassay and its interaction with the cells. These novel heterocycles are designed and synthesized by chemists through new strategies on par with the reported methods. Subsequently, the synthesized molecules were screened for their efficacy against the typical drugs in the market. In this article, recently unveiled pharmacologically important quinoline allied pyrazoles have been reviewed. Moreover, this review gives a bird’s-eye view of different methods adopted for synthesis in addition to the conventional approaches and also detailed study of the bioactive quinolinyl-pyrazole heterocycle when compared with standard drug-associated/having efficient molecule. We believe that this review will inspire synthetic as well as medicinal chemists who are in quest of less toxic and more potent quinolinyl-pyrazoles for the treatment of various health threats.

Graphic abstract

中文翻译：

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喹啉基-吡唑类化合物：近十年来的合成及其药理作用

摘要

近十年来对氮的研究杂环由于在许多重要领域的多功能性以及与生物测定及其与细胞相互作用相关的独特战斗而急剧增加。这些新颖的杂环是由化学家通过与所报道的方法相当的新策略设计和合成的。随后，对合成分子针对市场上典型药物的功效进行筛选。在本文中，对最近公开的具有重要药理作用的喹啉联苯并吡唑进行了综述。此外，本综述提供了除常规方法外的不同合成方法的鸟瞰图，以及与标准药物相关/具有有效分子的生物活性喹啉基-吡唑杂环的详细研究。

图形摘要