The cellular cytoskeleton consisting of microtubules, intermediate filaments and the actin filaments is a dynamic structure providing shape and structural stability to cells. Particularly, the actin cytoskeleton formed by a combination of polymerized actin molecules and several other actin binding proteins including myosin is key to sensing and development of mechanical forces in cells. Given this and other features, the actin cytoskeleton has been implicated in a variety of cellular process including cellular motility and migration, cytokinesis, phagocytosis, cytoplasmic streaming, organelle transport, cellular transformation and metastasis, cellular metabolism, cell–matrix adhesion, and cell–cell adhesion. The latter is mediated by E-cadherin in the epithelial tissue and is fundamental to tissue morphogenesis and normal development. Here we discuss the role of the actin cytoskeleton in the assembly and maintenance of E-cadherin-based cell–cell adhesion through the formation of cellular appendages such as filopodia and lamellipodia and thus, impinging on one of the fundamental features of multicellular organisms.

中文翻译：

---

肌动蛋白细胞骨架在基于 E-钙粘蛋白的细胞-细胞粘附组装和维持中的作用

由微管、中间丝和肌动蛋白丝组成的细胞骨架是一种动态结构，为细胞提供形状和结构稳定性。特别是，由聚合的肌动蛋白分子和包括肌球蛋白在内的几种其他肌动蛋白结合蛋白组合形成的肌动蛋白细胞骨架是细胞中机械力感知和发展的关键。鉴于此和其他特征，肌动蛋白细胞骨架涉及多种细胞过程，包括细胞运动和迁移、胞质分裂、吞噬作用、细胞质流动、细胞器运输、细胞转化和转移、细胞代谢、细胞-基质粘附和细胞-细胞粘附。后者由上皮组织中的 E-钙粘蛋白介导，是组织形态发生和正常发育的基础。