Background

Fecal microbiota transplantation (FMT) has been studied for the treatment of metabolic syndrome with varying success. However, the possibility of utilizing FMT to prevent metabolic syndrome is to date unknown.

Methods

Secondary analysis of a previously published double-blind, randomized, placebo-controlled pilot trial of FMT in obese metabolically healthy patients was conducted. Post-prandial glucose and insulin levels were measured (NCT02741518).

Results

A total of 22 patients were enrolled, 11 in each arm. There were no baseline differences in the area under the curve (AUC) of glucose or insulin in the FMT group compared to placebo. There was a significant change in glucose AUC at week 12 compared to baseline, and in the insulin AUC at week 6 compared to baseline in the FMT group vs. placebo (change in glucose AUC (mg/dl × 60 min): 579 vs 1978, p = 0.03) (change in insulin AUC (μU/ml × 60 min): 137 vs 2728, p = 0.01).

Conclusions

These data suggest that FMT may have a potential role in preventing the development of metabolic syndrome in patients with obesity.

中文翻译：

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胶囊粪便微生物群移植对预防肥胖患者代谢综合征的影响

背景

粪便微生物群移植 (FMT) 已被研究用于治疗代谢综合征，并取得了不同程度的成功。然而，迄今为止尚不清楚利用 FMT 预防代谢综合征的可能性。

方法

对先前发表的在肥胖代谢健康患者中进行 FMT 的双盲、随机、安慰剂对照试验性试验进行了二次分析。测量了餐后葡萄糖和胰岛素水平 (NCT02741518)。

结果

共招募了 22 名患者，每组 11 名。与安慰剂相比，FMT 组中葡萄糖或胰岛素的曲线下面积 (AUC) 没有基线差异。FMT 组与安慰剂组相比，第 12 周的葡萄糖 AUC 与基线相比有显着变化，第 6 周的胰岛素 AUC 与基线相比有显着变化（葡萄糖 AUC 的变化（mg/dl × 60 分钟）：579 与 1978 , p  = 0.03)（胰岛素 AUC 的变化（μU/ml × 60 分钟）：137 对 2728，p  = 0.01）。

结论

这些数据表明 FMT 可能在预防肥胖患者发生代谢综合征方面具有潜在作用。