当前位置: X-MOL 学术Chem. Pap. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Synthesis of nanotubular oxide on Ti–24Zr–10Nb–2Sn as a drug-releasing system to prevent the growth of Staphylococcus aureus
Chemical Papers ( IF 2.2 ) Pub Date : 2021-01-10 , DOI: 10.1007/s11696-020-01495-6
Luis López-Pavón , Daniel Dagnino-Acosta , Enrique López-Cuéllar , Frank Meléndez-Anzures , Diana Zárate-Triviño , María Barrón-González , Iván Moreno-Cortez , Hee Young Kim , Shuichi Miyazaki

The aim in the present study was to explore the potential application of titanium nanotubes developed in the Ti–24Zr–10Nb–2Sn alloy, as drug delivery systems to prevent bacterial infections in medical devices. A nanotubular oxide layer was synthesized by electrochemical anodizing on the Ti–24Zr–10Nb–2Sn superelastic alloy and the electrical variables that control the growth at constant potential were determined. Scanning electron microscopy (SEM) showed that the nanostructures show a positive linear growth as a function of the applied potential, the superficial analysis carried out by X-ray photoelectron spectroscopy (XPS) showed different states of valence evidencing the presence of TiO2, Nb2O5, SnO2, and ZrO2. FTIR spectra confirm the presence of the antibiotic gentamicin in the Ti–24Zr–10Nb–2Sn nanotubes. The developed nanostructures were evaluated in a phosphate buffer solution (PBS) as a controlled release system of antibiotics. It was observed by bacteriological tests that the nanostructured morphology in combination with the chemical composition has bacteriostatic properties; while the release of the antibiotic-loaded inside the nanotubes had a bactericidal effect. The results showed that it is possible to grow and control the morphology of the developed nanostructures on Ti–24Zr–10Nb–2Sn, which can be used for orthopedic purposes to transport and control the local release of molecules like antibiotics at the site of interest and thus prevent postoperative infections.

Graphic abstract



中文翻译:

在Ti–24Zr–10Nb–2Sn上合成纳米管氧化物,作为防止金黄色葡萄球菌生长的药物释放系统

本研究的目的是探索在Ti–24Zr–10Nb–2Sn合金中开发的钛纳米管作为预防医疗器械中细菌感染的药物输送系统的潜在应用。通过在Ti–24Zr–10Nb–2Sn超弹性合金上进行电化学阳极氧化,合成了纳米管氧化物层,并确定了控制恒定电势下生长的电变量。扫描电子显微镜(SEM)显示,纳米结构显示正线性增长,与所施加的电势有关,通过X射线光电子能谱(XPS)进行的表面分析表明,价态不同,表明存在TiO 2,Nb 2 O 5,SnO 2和ZrO 2。FTIR光谱证实了Ti-24Zr-10Nb-2Sn纳米管中存在庆大霉素抗生素。在磷酸盐缓冲溶液(PBS)中评估了已开发的纳米结构,将其作为抗生素的控释系统。通过细菌学测试观察到,纳米结构形态与化学组成相结合具有抑菌特性。同时释放载于纳米管中的抗生素具有杀菌作用。结果表明,可以生长和控制Ti–24Zr–10Nb–2Sn上发达的纳米结构的形貌,可将其用于整形外科目的,以在感兴趣的部位转运和控制诸如抗生素等分子的局部释放。从而防止术后感染。

图形摘要

更新日期:2021-01-10
down
wechat
bug