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microRNAs Promoting Growth of Gastric Cancer Xenografts and Correlation to Clinical Prognosis.
Cancer Genomics & Proteomics ( IF 2.5 ) Pub Date : 2021-01-08 , DOI: 10.21873/cgp.20237
Ulrich H Weidle 1 , Fabian Birzele 2 , Adam Nopora 1
Affiliation  

The annual death toll for gastric cancer is in the range of 700,000 worldwide. Even in patients with early-stage gastric cancer recurrence within five years has been observed after surgical resection and following chemotherapy with therapy-resistant features. Therefore, the identification of new targets and treatment modalities for gastric cancer is of paramount importance. In this review we focus on the role of microRNAs with documented efficacy in preclinical xenograft models with respect to growth of human gastric cancer cells. We have identified 31 miRs (-10b, -19a, -19b, -20a, -23a/b, -25, -27a-3p, -92a, -93, -100, -106a, -130a, -135a, -135b-5p, -151-5p, -187, -199-3p, -215, -221-3p, -224, -340a, -382, -421, -425, -487a, -493, -532-3p, -575, -589, -664a-3p) covering 26 different targets which promote growth of gastric cancer cells in vitro and in vivo as xenografts. Five miRs (miRs -10b, 151-5p, -187, 532-3p and -589) additionally have an impact on metastasis. Thirteen of the identified miRs (-19b, -20a/b, -25, -92a, -106a, -135a, -187, -221-3p, -340a, -421, -493, -575 and -589) have clinical impact on worse prognosis in patients.

中文翻译:

microRNAs 促进胃癌异种移植物的生长和与临床预后的相关性。

全球每年因胃癌死亡的人数在 70 万左右。甚至在五年内早期胃癌复发的患者中也观察到在手术切除和化疗后具有治疗抵抗特征。因此,确定胃癌的新靶点和治疗方式至关重要。在这篇综述中,我们重点研究了在临床前异种移植模型中具有记录功效的 microRNA 在人类胃癌细胞生长方面的作用。我们已经鉴定了 31 个 miR(-10b、-19a、-19b、-20a、-23a/b、-25、-27a-3p、-92a、-93、-100、-106a、-130a、-135a、- 135b-5p、-151-5p、-187、-199-3p、-215、-221-3p、-224、-340a、-382、-421、-425、-487a、-493、-532-3p , -575, -589, -664a-3p) 覆盖了 26 个不同的靶标,这些靶标促进了胃癌细胞在体外和体内作为异种移植物的生长。五种 miR(miRs -10b、151-5p、-187、532-3p 和 -589)另外对转移有影响。已鉴定的 13 个 miR(-19b、-20a/b、-25、-92a、-106a、-135a、-187、-221-3p、-340a、-421、-493、-575 和 -589)具有对患者预后较差的临床影响。
更新日期:2021-01-11
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