Colorectal cancer frustrates with high relapse after the traditional treatment including surgery and chemotherapy. Neoantigen-based therapeutic vaccine has achieved high response rate in the clinical trials rising the immunotherapy as a promising alternative for colorectal cancer. Herein, colon cancer cells derived neoantigen peptide Adpgk were employed to be co-encapsulated with black phosphorus quantum dots into liposome (Adpgk-BPQDs-liposome) as therapeutic vaccine. Adpgk-BPQDs-liposome were dispersed in F127 gel containing GM-CSF. The heat generated by black phosphorus (BP) under 808 nm near-infrared laser irradiation accelerates the F127 gel ablation and the release of GM-CSF, which recruit APC cells and prime the native T cells. The tumor bearing mice received the programmed cell death protein 1 (PD-1) checkpoint blockade antibody combined with photo-thermal gel intensively prevented the tumor progress. Furthermore, the tumor infiltrating CD8+ T cells were significantly increased which lead to the elimination of the tumor.

中文翻译：

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包裹新抗原和黑磷量子点的脂质体用于增强光热免疫疗法。

结直肠癌在包括手术和化疗在内的传统治疗后复发率高。基于新抗原的治疗性疫苗在临床试验中取得了高反应率，使免疫疗法成为结直肠癌的有希望的替代方案。在此，结肠癌细胞衍生的新抗原肽Adpgk被用于与黑磷量子点共封装成脂质体（Adpgk-BPQDs-liposome）作为治疗性疫苗。Adpgk-BPQDs-脂质体分散在含有GM-CSF的F127凝胶中。黑磷 (BP) 在 808 nm 近红外激光照射下产生的热量加速了 F127 凝胶消融和 GM-CSF 的释放，从而募集 APC 细胞并启动天然 T 细胞。荷瘤小鼠接受程序性细胞死亡蛋白 1 (PD-1) 检查点阻断抗体联合光热凝胶强化阻止肿瘤进展。此外，肿瘤浸润性CD8+ T细胞显着增加，导致肿瘤消失。