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Molecular Characteristics of N1-Methyladenosine Regulators and Their Correlation with Overall Cancer Survival
DNA and Cell Biology ( IF 3.1 ) Pub Date : 2021-03-04 , DOI: 10.1089/dna.2020.6214
Juan Li 1, 2 , Chunting Zhang 1, 2 , Xin Yuan 1, 2 , Yuan Cao 3
Affiliation  

N1-methyladenosine (m1A) is a prevalent RNA modification widely affecting RNA structural stability, folding, and interactions with proteins. Recently, there have been increasing reports on the roles of m1A regulators in tumors. However, their mechanisms and clinical relevance remain unclear. This study systematically evaluates the epigenetic characteristics and clinical relevance of m1A regulators using bioinformatic methods. Our results show widespread gene expression changes for m1A regulators, which are related to the activation and inhibition of carcinogenic pathways and overall patient survival. Collectively, this investigation provides new insights into assessing tumor prognosis and targeted therapy.

中文翻译:

N1-甲基腺苷调节剂的分子特征及其与总生存期的关系

N1-甲基腺苷(m1A)是一种普遍的RNA修饰,广泛影响RNA的结构稳定性,折叠以及与蛋白质的相互作用。近来,关于m1A调节剂在肿瘤中的作用的报道越来越多。但是,它们的机制和临床相关性仍不清楚。这项研究使用生物信息学方法系统评估了m1A调节剂的表观遗传学特征和临床相关性。我们的结果表明,m1A调节剂的基因表达发生了广泛变化,这与致癌途径的激活和抑制以及患者的总体生存率有关。总的来说,这项研究为评估肿瘤的预后和靶向治疗提供了新的见识。
更新日期:2021-03-09
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