In recent years, a variety of receptor-targeted fluorescent probes have been developed and widely used to realize the visualization of certain receptors, which facilitates the early diagnosis and treatment of diseases. In this Review, we focus on the recent achievements in design, chemical structure, imaging characterization, and potential applications of receptor-targeted fluorescent probes from the past 10 years. The development and application of receptor-targeted fluorescent probes will expand our knowledge of the distribution and function of disease-related receptors, shed light on the drug discovery for clinical diseases where receptors are implicated, and feed into the diagnosis and treatment of a plethora of diseases, including tumors.

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基于小分子荧光染料的受体靶向荧光探针的设计与应用

近年来，多种受体靶向荧光探针被开发并广泛用于实现某些受体的可视化，从而促进疾病的早期诊断和治疗。在这篇综述中，我们重点介绍了过去 10 年来受体靶向荧光探针在设计、化学结构、成像表征和潜在应用方面的最新成就。受体靶向荧光探针的开发和应用将扩大我们对疾病相关受体分布和功能的认识，阐明与受体有关的临床疾病的药物发现，并为多种疾病的诊断和治疗提供依据。疾病，包括肿瘤。