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The VCBS superfamily forms a third supercluster of β-propellers that includes tachylectin and integrins
Bioinformatics ( IF 5.8 ) Pub Date : 2021-01-08 , DOI: 10.1093/bioinformatics/btaa1085
Joana Pereira 1 , Andrei N Lupas 1
Affiliation  

β-Propellers are found in great variety across all kingdoms of life. They assume many cellular roles, primarily as scaffolds for macromolecular interactions and catalysis. Despite their diversity, most β-propeller families clearly originated by amplification from the same ancient peptide—the “blade”. In cluster analyses, β-propellers of the WD40 superfamily always formed the largest group, to which some important families, such as the α-integrin, Asp-box, and glycoside hydrolase β-propellers connected weakly. Motivated by the dramatic growth of sequence databases we revisited these connections, with a special focus on VCBS-like β-propellers, which have not been analysed for their evolutionary relationships so far.

中文翻译:

VCBS 超家族形成了 β-螺旋桨的第三个超簇,其中包括速凝素和整合素

β-螺旋桨在生命的各个领域都有很多种。它们承担许多细胞角色,主要是作为大分子相互作用和催化的支架。尽管存在多样性,但大多数 β-螺旋桨家族显然起源于同一古老肽——“叶片”的扩增。在聚类分析中,WD40 超家族的 β-螺旋桨总是构成最大的组,一些重要的家族,如 α-整合素、Asp-box 和糖苷水解酶 β-螺旋桨与该组弱连接。受序列数据库急剧增长的推动,我们重新审视了这些联系,特别关注类 VCBS 的 β-螺旋桨,迄今为止尚未分析它们的进化关系。
更新日期:2021-01-08
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