One avenue to address the paucity of clinically testable targets is to reinvestigate the druggable genome by tackling complicated types of targets such as Protein-Protein Interactions (PPIs). Given the challenge to target those interfaces with small chemical compounds, it has become clear that learning from successful examples of PPI modulation is a powerful strategy. Freely-accessible databases of PPI modulators that provide the community with tractable chemical and pharmacological data, as well as powerful tools to query them, are therefore essential to stimulate new drug discovery projects on PPI targets.

中文翻译：

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iPPI-DB 倡议：以社区为中心的蛋白质-蛋白质相互作用调节剂数据库

解决临床可测试靶标缺乏问题的一种途径是通过处理复杂类型的靶标（例如蛋白质-蛋白质相互作用 (PPI)）来重新研究药物基因组。鉴于用小化合物定位这些界面的挑战，很明显，从 PPI 调制的成功例子中学习是一种强大的策略。因此，可免费访问的 PPI 调节剂数据库为社区提供易于处理的化学和药理学数据，以及查询这些数据的强大工具，对于刺激针对 PPI 目标的新药发现项目至关重要。