Frontiers in Molecular Biosciences ( IF 5 ) Pub Date : 2020-12-08 , DOI: 10.3389/fmolb.2020.617633 Pilar Menendez-Gil , Alejandro Toledo-Arana
Bacterial messenger RNAs (mRNAs) are composed of 5′ and 3′ untranslated regions (UTRs) that flank the coding sequences (CDSs). In eukaryotes, 3′UTRs play key roles in post-transcriptional regulatory mechanisms. Shortening or deregulation of these regions is associated with diseases such as cancer and metabolic disorders. Comparatively, little is known about the functions of 3′UTRs in bacteria. Over the past few years, 3′UTRs have emerged as important players in the regulation of relevant bacterial processes such as virulence, iron metabolism, and biofilm formation. This MiniReview is an update for the different 3′UTR-mediated mechanisms that regulate gene expression in bacteria. Some of these include 3′UTRs that interact with the 5′UTR of the same transcript to modulate translation, 3′UTRs that are targeted by specific ribonucleases, RNA-binding proteins and small RNAs (sRNAs), and 3′UTRs that act as reservoirs of
中文翻译:
细菌3'UTR:转录后调控中的有用资源
细菌信使RNA(mRNA)由位于编码序列(CDS)两侧的5'和3'非翻译区(UTR)组成。在真核生物中,3'UTR在转录后调控机制中起关键作用。这些区域的缩短或失调与诸如癌症和代谢紊乱的疾病有关。相比之下,对细菌中3'UTR的功能了解甚少。在过去的几年中,3'UTR已成为调节相关细菌过程(如毒力,铁代谢和生物膜形成)的重要参与者。该MiniReview是对3'UTR介导的调节细菌基因表达的不同机制的更新。其中一些包括与同一转录本的5'UTR相互作用以调节翻译的3'UTR,特定核糖核酸酶靶向的3'UTR,