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The Dynamic Roles of the Inner Membrane Complex in the Multiple Stages of the Malaria Parasite
Frontiers in Cellular and Infection Microbiology ( IF 5.7 ) Pub Date : 2020-11-30 , DOI: 10.3389/fcimb.2020.611801
Josie Liane Ferreira 1, 2 , Dorothee Heincke 3, 4 , Jan Stephan Wichers 1, 3, 4 , Benjamin Liffner 5 , Danny W Wilson 5, 6 , Tim-Wolf Gilberger 1, 3, 4
Affiliation  

Apicomplexan parasites, such as human malaria parasites, have complex lifecycles encompassing multiple and diverse environmental niches. Invading, replicating, and escaping from different cell types, along with exploiting each intracellular niche, necessitate large and dynamic changes in parasite morphology and cellular architecture. The inner membrane complex (IMC) is a unique structural element that is intricately involved with these distinct morphological changes. The IMC is a double membrane organelle that forms de novo and is located beneath the plasma membrane of these single-celled organisms. In Plasmodium spp. parasites it has three major purposes: it confers stability and shape to the cell, functions as an important scaffolding compartment during the formation of daughter cells, and plays a major role in motility and invasion. Recent years have revealed greater insights into the architecture, protein composition and function of the IMC. Here, we discuss the multiple roles of the IMC in each parasite lifecycle stage as well as insights into its sub-compartmentalization, biogenesis, disassembly and regulation during stage conversion of P. falciparum.



中文翻译:

内膜复杂在疟原虫的多个阶段中的动态作用。

蚜虫寄生虫,例如人类疟疾寄生虫,具有复杂的生命周期,涵盖了多种多样的环境生态位。从不同的细胞类型入侵,复制和逃逸,以及利用每个细胞内的利基,有必要对寄生虫形态和细胞结构进行大而动态的改变。内膜复合物(IMC)是独特的结构元素,与这些独特的形态变化错综复杂地联系在一起。IMC是形成的双膜细胞器从头并且位于这些单细胞生物的质膜下方。在疟原虫spp。寄生虫具有三个主要目的:赋予细胞稳定性和形状,在子代细胞形成过程中充当重要的支架隔室,并在运动和侵袭中起主要作用。近年来,人们对IMC的结构,蛋白质组成和功能有了更深入的了解。在这里,我们讨论了IMC在每个寄生虫生命周期阶段的多重作用,以及对IMC阶段转化过程中亚小室化,生物发生,拆卸和调节的见解。恶性疟原虫

更新日期:2021-01-08
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