It was suggested that the brain-heart connection is asymmetrically organized. However, evidence connecting neurochemical factors from each brain hemisphere with changes in cardio-vascular functions have not yet been reported. In order to analyze potential asymmetrical connections between brain neurochemical factors with cardio-vascular functions, we studied the level of correlations between the left and right frontal cortex (FC) soluble (Sol) and membrane-bound (MB) neuropeptide-degrading enzymes alanyl (AlaAP), cystinyl (CysAP), and glutamyl (GluAP) aminopeptidase activities, involved among others in the metabolism of angiotensins, with heart rate (HR), systolic (SBP), and diastolic (DBP) blood pressure, in rats treated or not with hypotensive or hypertensive drugs such as captopril, propranolol or L-NAME. The present study suggests the existence of a bidirectional asymmetrical connection between these brain neuropeptidases and cardio-vascular functions. Specifically, depending on treatment, in control group, Sol AlaAP from the left FC correlates negatively with SBP and DBP. In captopril-treated animals, MB CysAP and MB GluAP from the right FC correlate negatively with HR. In L-NAME treated rats, Sol CysAP from the right FC correlates negatively with DBP. No significant correlations were observed in the propranolol group. Considering together all the values obtained from the left or the right cortex of the four groups regardless of drug treatment, the results demonstrated significant negative correlations between these neuropeptidase activities, mainly from the left frontal cortex, with the levels of systolic and diastolic blood pressure. Remarkably, these findings contrast drastically with previously reported results indicating significant positive correlations between the left frontal cortex with other peripheral functions such as water intake and diuresis. Both results represent noteworthy information that strongly supports the concept of a bidirectional asymmetric organization of neurovisceral integration involving left and right brain neurochemical processes with peripheral physiological functions, most probably mediated by the autonomic nervous system. Overall, the present results suggest that cognitive functions involving the frontal cortex may be asymmetrically connected with peripheral physiological processes, and vice versa.

中文翻译：

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血压与左右额叶皮层的神经肽酶活性不对称相关

有人认为脑心联系是不对称的。然而，尚未报道将每个大脑半球的神经化学因子与心血管功能变化联系起来的证据。为了分析大脑神经化学因子与心血管功能之间的潜在不对称联系，我们研究了左和右额叶皮质（FC）可溶性（Sol）与膜结合（MB）的神经肽降解酶丙氨酰（ AlaAP），胱氨酰（CysAP）和谷氨酰（GluAP）氨肽酶活性与血管紧张素的代谢有关，并伴有心率（HR），收缩压（SBP）和舒张压（DBP）血压与降压或高血压药物（如卡托普利，普萘洛尔或L-NAME）配合使用。本研究表明这些脑神经肽酶和心血管功能之间存在双向不对称连接。具体而言，根据治疗情况，在对照组中，来自左FC的Sol AlaAP与SBP和DBP呈负相关。在卡托普利治疗的动物中，右侧FC的MB CysAP和MB GluAP与HR呈负相关。在接受L-NAME治疗的大鼠中，来自右FC的Sol CysAP与DBP负相关。在心得安组中未观察到显着相关性。综合考虑从四组左皮质或右皮质获得的所有值，而不考虑药物治疗，结果表明这些神经肽酶活性（主要来自左额叶皮质）与收缩压和舒张压水平之间呈显着负相关。值得注意的是，这些发现与先前报道的结果形成了鲜明的对比，表明左额叶皮层与其他外周功能（如进水和利尿）之间存在显着的正相关。这两个结果都代表了值得注意的信息，这些信息强有力地支持了神经内脏整合的双向不对称组织的概念，该组织涉及具有周围生理功能的左，右脑神经化学过程，最有可能是由自主神经系统介导的。总的来说，目前的结果表明涉及额叶皮质的认知功能可能与周围的生理过程不对称地联系在一起，反之亦然。这些发现与先前报道的结果形成了鲜明的对比，表明左额叶皮层与其他外周功能（如进水和利尿）之间存在显着的正相关。这两个结果都代表了值得注意的信息，这些信息强有力地支持了神经内脏整合的双向不对称组织的概念，该组织涉及具有周围生理功能的左，右脑神经化学过程，最有可能是由自主神经系统介导的。总的来说，目前的结果表明涉及额叶皮质的认知功能可能与周围的生理过程不对称地联系在一起，反之亦然。这些发现与先前报道的结果形成了鲜明的对比，表明左额叶皮层与其他外周功能（如进水和利尿）之间存在显着的正相关。这两个结果都代表了值得注意的信息，这些信息强有力地支持了神经内脏整合的双向不对称组织的概念，该组织涉及具有周围生理功能的左，右脑神经化学过程，最有可能是由自主神经系统介导的。总的来说，目前的结果表明涉及额叶皮质的认知功能可能与周围的生理过程不对称地联系在一起，反之亦然。这两个结果都代表了值得注意的信息，这些信息强有力地支持了神经内脏整合的双向不对称组织的概念，该组织涉及具有周围生理功能的左，右脑神经化学过程，最有可能是由自主神经系统介导的。总的来说，目前的结果表明涉及额叶皮质的认知功能可能与周围的生理过程不对称地联系在一起，反之亦然。这两个结果都代表了值得注意的信息，这些信息强有力地支持了神经内脏整合的双向不对称组织的概念，该组织涉及具有周围生理功能的左，右脑神经化学过程，最有可能是由自主神经系统介导的。总的来说，目前的结果表明涉及额叶皮质的认知功能可能与周围的生理过程不对称地联系在一起，反之亦然。