Oxidative stress plays a pivotal role in the progression of chronic hepatitis B; however, it is unclear whether the status of blood oxidative stress and antioxidant components differs depending on the degree of hepatic fibrosis. To explore the relationship between oxidative stress/antioxidant capacity and the extent of hepatic fibrosis, fifty-four subjects with liver fibrosis (5.5 ≤ liver stiffness measurement (LSM) score ≤ 16.0 kPa) by chronic hepatitis B virus (HBV) were analyzed. From the analysis of eight kinds of serum oxidative stress/antioxidant profiles and liver fibrosis degrees, the level of total antioxidant capacity (TAC) reflected a negative correlation with the severity of hepatic fibrosis (Pearson correlation, r = −0.35, p = 0.01). Moreover, TAC showed higher sensitivity (73.91%) than the aspartate transaminase (AST) to platelet ratio index (APRI, 56.52%) in the receiver operating characteristic (ROC) curves. Interestingly, the TAC level finely reflected the fibrosis degree in inactive carriers (HBV DNA < 2000 IU/mL), while the APRI did in active carriers (HBV DNA > 2000 IU/mL). In conclusion, TAC is a promising biomarker for evaluating the progression of liver fibrosis in patients with HBV, and this finding may indicate the involvement of TAC-composing factors in the pathogenesis of hepatic fibrosis in chronic HBV carriers.

中文翻译：

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HBV携带者的总抗氧化能力，评估肝纤维化的有前途的生物标志物：一项初步研究

氧化应激在慢性乙型肝炎的进展中起关键作用。但是，根据肝纤维化程度，血液氧化应激和抗氧化剂成分的状态是否不同尚不清楚。为了探讨氧化应激/抗氧化能力与肝纤维化程度之间的关系，分析了五十四名慢性乙型肝炎病毒（HBV）引起的肝纤维化受试者（5.5≤肝硬度测量值（LSM）评分≤16.0 kPa）。通过分析八种血清氧化应激/抗氧化剂谱和肝纤维化程度，总抗氧化能力（TAC）水平与肝纤维化严重程度呈负相关（Pearson相关，r = -0.35，p = 0.01） 。此外，TAC显示出更高的灵敏度（73。接收器工作特征（ROC）曲线中的天冬氨酸转氨酶（AST）与血小板比率指数（APRI，56.52％）的比率为91％。有趣的是，TAC水平可以很好地反映非活性载体（HBV DNA <2000 IU / mL）中的纤维化程度，而APRI可以反映活性载体（HBV DNA> 2000 IU / mL）中的纤维化程度。总之，TAC是评估HBV患者肝纤维化进展的有前途的生物标志物，这一发现可能表明TAC组成因子参与了慢性HBV携带者肝纤维化的发病机制。